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. 1996 Jan 22;707(1):131-3.
doi: 10.1016/0006-8993(95)01371-7.

The determination of the extracellular concentration of brain glutamate using quantitative microdialysis

M Miele  1 , M Berners, M G Boutelle, H Kusakabe, M Fillenz
Affiliations

The determination of the extracellular concentration of brain glutamate using quantitative microdialysis

M Miele et al. Brain Res. .

Abstract

Quantitative microdialysis with two enzyme-based assays was used to determine the extracellular concentration of glutamate in the striatum of freely moving rats. From the difference between infused and dialysate glutamate a value of 3.0 +/- 0.6 microM for the extracellular glutamate concentration was computed by regression analysis. The in vivo recovery, derived from the slope of the regression line, was 50%.

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