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. 1996 Aug;17(7):1283-9.

Premature aging in persons with Down syndrome: MR findings

G M Roth  1 , B Sun, F S Greensite, I T Lott, R B Dietrich
Affiliations

Premature aging in persons with Down syndrome: MR findings

G M Roth et al. AJNR Am J Neuroradiol. 1996 Aug.

Abstract

Purpose: To determine whether persons with Down syndrome have features of premature aging on routine MR imaging sequences.

Methods: Sixty MR studies (in 30 persons with Down syndrome and 30 age- and sex-matched control subjects) were reviewed retrospectively by two blinded examiners. Sagittal T1-weighted and axial T2-weighted spin-echo images were evaluated for the presence and severity of three markers of brain aging: atrophy, white matter lesions, and T2 hypointensity of the basal ganglia, referenced to the examiner's internal standard of normal for that age and sex.

Results: Persons with Down syndrome had higher prevalence and severity of the three markers studied than the control subjects. Atrophy and white matter lesions increased in prevalence with age; abnormal T2 hypointensity of the basal ganglia was more equally distributed with age.

Conclusion: Persons with Down syndrome have features of premature aging detectable at routine MR imaging.

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