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. 1996 Aug 20;95(1):131-4.
doi: 10.1016/0165-3806(96)00087-9.

Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice

E Fride  1 , R Mechoulam
Affiliations

Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice

E Fride et al. Brain Res Dev Brain Res. .

Abstract

We studied the ontogenetic response to cannabinoid receptor ligands by measuring motor activity and analgesia in response to anandamide or delta 9-THC from day 6 of age. No response to anandamide was observed up to the age of weaning (day 23), while a nonsignificant response to delta 9-THC was observed starting between days 15 and 20. This is compatible with observations that children respond to the antiemetic effects of THC without psychotropic side effects.

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