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Case Reports
. 1996 Sep;155(9):775-9.
doi: 10.1007/BF02002905.

Severe tick-borne encephalitis following passive immunization

K Waldvogel  1 , W Bossart, T Huisman, E Boltshauser, D Nadal
Affiliations
Case Reports

Severe tick-borne encephalitis following passive immunization

K Waldvogel et al. Eur J Pediatr. 1996 Sep.

Abstract

We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing numbers of B-cells after initial T-cell pleocytosis. Focal central lesions were evident on MRI.

Conclusion: The severity of the presented case questions the benefit of passive immunization and rather justifies consideration of vaccine recommendation to residents and travellers to areas endemic for tick-borne encephalitis virus.

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