Neuroendocrine differentiation in the precursors of prostate cancer
- PMID: 8875199
- DOI: 10.1159/000474168
Neuroendocrine differentiation in the precursors of prostate cancer
Abstract
Objectives: To review neuroendocrine differentiation in the precursors of prostatic carcinoma (prostatic intraepithelial neoplasia).
Methods: Background information is given on the prostatic neuroendocrine cell and neuroendocrine differentiation in prostatic carcinoma. Neuroendocrine differentiation in prostatic intraepithelial neoplasia is reviewed.
Results: Neuroendocrine differentiation occurs in prostatic intraepithelial neoplasia and is intermediate in degree between normal (which has the most cells with neuroendocrine differentiation) and carcinoma.
Conclusion: Neuroendocrine differentiation in the precursors of prostatic carcinoma may play a role in the pathogenesis of cancer but is speculative at this time. Methods to better assess neuroendocrine differentiation are needed.
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