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Review
. 1996 Sep;7(5):553-9.
doi: 10.1007/BF00051889.

Big babies and infant leukemia: a role for insulin-like growth factor-1?

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Review

Big babies and infant leukemia: a role for insulin-like growth factor-1?

J A Ross et al. Cancer Causes Control. 1996 Sep.

Abstract

Several epidemiologic studies have demonstrated that high birthweight is associated with an increased risk of infant leukemia; however, the reason for this relationship is unclear. Biologic data demonstrate that birth weight is correlated positively with circulating levels of insulin-like growth factor-1 (IGF-1). IGF-1 is important in blood formation and regulation and has been shown to stimulate the growth of both myeloid and lymphoid cells in culture. Since infants who develop leukemia are likely to have had at least one transforming event occur in utero, we hypothesize that high levels of IGF-1 may both produce a larger baby and contribute to leukemogenesis.

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References

    1. Leukemia. 1989 May;3(5):328-34 - PubMed
    1. Am J Obstet Gynecol. 1987 Dec;157(6):1524-8 - PubMed
    1. J Pediatr. 1997 Nov;131(5):671-7 - PubMed
    1. Ann Epidemiol. 1997 Apr;7(3):172-9 - PubMed
    1. Acta Endocrinol (Copenh). 1992 Oct;127(4):359-65 - PubMed

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