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. 1996 Aug;106(2):223-7.
doi: 10.1007/BF02484404.

Histochemical staining of cadmium with 2-(8-quinolylazo)-4,5-diphenylimidazole

Y Sumi  1 , M T Itoh, T Muraki, T Suzuki
Affiliations

Histochemical staining of cadmium with 2-(8-quinolylazo)-4,5-diphenylimidazole

Y Sumi et al. Histochem Cell Biol. 1996 Aug.

Abstract

In order to develop a stain with increased sensitivity and selectivity for cadmium (Cd), we synthesized and characterized 2-(8-quinolylazo)-4,5-diphenylimidazole (QAI). This chelating agent was more than twice as sensitive for Cd than the best conventional staining agents, including benzothiazolylazo-beta-naphthol. Differentiation between Cd and zinc (Zn) was achieved by immersing tissue sections in TRIS(2-aminoethyl)amine before they were stained with QAI. This pretreatment made it possible to selectively stain for Cd by blocking Zn.

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