Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Aug;38(2):245-51.
doi: 10.1093/jac/38.2.245.

Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein

R B Clark  1
Affiliations

Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein

R B Clark. J Antimicrob Chemother. 1996 Aug.

Abstract

The mechanism of imipenem resistance of two Acinetobacter baumannii isolates (A-1 and A-24) was characterized in this study. A spontaneous revertant (A-1 (rev)) derived from isolate A-1 showed susceptibility to imipenem. beta-Lactamase hydrolysis studies showed no evidence of an imipenem hydrolyzing enzyme among A-1, A-24, A-1 (rev), or two other imipenem susceptible A. baumannii isolates. Outer membrane protein (OMP) analysis indicated decreased expression of a 33-36 kDa protein by isolates A-1 and A-24 when compared with A-1 (rev) and the other A. baumannii isolates. In conclusion, decreased expression of a 33-36 kDa OMP is associated with imipenem resistance among A. baumannii.

PubMed Disclaimer

MeSH terms

LinkOut - more resources