Vitellogenin receptors: oocyte-specific members of the low-density lipoprotein receptor supergene family

Abstract

Receptors that transport vitellogenin (VTG) into oocytes are of vital importance to egg-laying species, because they mediate a key step of oocyte maturation, a prerequisite to reproduction. Vitellogenins are lipophosphoglycoproteins that are produced under female hormonal control in large central organs (fat body in insects; liver in higher animals) and are transported in the circulation to the female gonads. VTG receptors localized in coated pits on the surface of growth-competent oocytes are able to accumulate in the yolk high concentrations of VTG and other ligands they recognize. The study of VTG receptors and their ligands has identified genes that specify related ligands, and a family of receptors. To date, all molecularly characterized VTG receptors belong to the low-density lipoprotein receptor supergene family, which ranges from a 600-kDa receptor in Caenorhabditis elegans to the 100-kDa so-called very-low-density lipoprotein receptors in mammals. These receptors, by and large, recognize ligands with similarities in structural elements first defined in the human apoplipoproteins B-100 and E. Recent studies on the receptor family have added VTG and lipoprotein lipase to the list of co-evolved ligands and have revealed that VTG receptors are able to interact with ligands other than VTG and also with some unrelated to lipoprotein metabolism. For example, the chicken VTG receptor also imports very-low-density lipoprotein, riboflavin-binding protein, and alpha-2-macroglobulin into growing oocytes. Such multifunctionality of receptors is likely the result of evolutionary pressure to provide the female germ cell with a highly economical machinery for vitellogenesis.