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. 1996 Jul-Sep;40(3):567-71.

Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus

M K Hassan  1 , M Q Al-Natour, L A Ward, Y M Saif
Affiliations
  • PMID: 8883785

Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus

M K Hassan et al. Avian Dis. 1996 Jul-Sep.

Abstract

An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF chickens vaccinated with the attenuated IN virus used as a live or inactivated vaccine followed by homologous (IN) and heterologous (STC) challenge with bursa-derived viruses.

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