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Clinical Trial
. 1996;193(2):124-6.
doi: 10.1159/000246226.

Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy

F Ott  1 , W Bollag, J M Geiger
Affiliations
Clinical Trial

Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy

F Ott et al. Dermatology. 1996.

Abstract

Background: 9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters.

Objective: Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study.

Methods: Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses.

Results: No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA.

Conclusion: For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.

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