[Serum concentration of the pregnancy-associated alpha2 glycoprotein (alpha2-PAG, protein of the "pregnancy zone", PZ) in malignant gynecologic diseases]

Abstract

The concentration of pregnancy-associated alpha2-glycoprotein (alpha2-PAG, PZ) was investigated by means of electroimmunodiffusion and single radial immunodiffusion in sera of 30 patients suffering from malignant genital diseases. Results of electroimmunodiffusion indicate that surgical and/or radiological treatment is followed by a significant decrease of PZ serum level. But few months later values have been measured as detected before therapy. There were no significant differences of PZ levels in dependence on localization, histological findings and stage of gynaecological cancer. These findings indicate that periodic determinations of serum PZ do not supply the diagnosis for controlling the course of gynaecological cancer.