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Review
. 1996 Oct;23(12):1669-72.

[Inhibitory effect of FOY-305 on liver metastasis of the pancreatic cancer]

[Article in Japanese]
T Ohta  1 , F Futagami, H Arakawa, Y Tsukioka, H Kitagawa, M Kayahara, T Nagakawa, I Miyazaki
Affiliations
  • PMID: 8886041
Review

[Inhibitory effect of FOY-305 on liver metastasis of the pancreatic cancer]

[Article in Japanese]
T Ohta et al. Gan To Kagaku Ryoho. 1996 Oct.

Abstract

The potential for hepatic metastasis in nude mice was studied by the intrasplenic implantation method with five human pancreatic cancer cell lines, Capan-1, BxPC-3, AsPC-1, Panc-1, and MIAPaCa-2, especially in relation to serine protease expression, including urokinase-type plasminogen activator and pancreatic trypsinogen 1 (cationic form). The inhibitory effect of a serine protease inhibitor agent, FOY-305, on hepatic metastasis was also a assessed. As a result, the potential for hepatic metastasis was well correlated with expression of pancreatic trypsinogen 1 in these cell lines, and the incidence of metastasis was significantly decreased by FOY-305. These findings suggest that pharmacologic inhibition of serine protease activity may be a new strategy for the therapy of pancreatic cancer metastasis.

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