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. 1979 Aug 1;134(7):734-8.
doi: 10.1016/0002-9378(79)90938-4.

Human fibroblasts produce "pregnancy-specific" beta-1 glycoprotein in vitro

S W Rosen, J Kaminska, I S Calvert, S A Aaronson

Human fibroblasts produce "pregnancy-specific" beta-1 glycoprotein in vitro

S W Rosen et al. Am J Obstet Gynecol. .

Abstract

Normal and genetic variant strains of nonmalignant human fibroblasts produce in vitro a substance indistinguishable from the recently described "pregnancy-specific" beta-1 glycoprotein (PSbetaG, PAPP-C, SP1). Demonstration of this presumed placenta-specific material in a nonplacental site raises questions about its normal physiologic role and use as a cancer marker.

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