Cross-correlation studies of movement-related cortical potentials during unilateral and bilateral muscle contractions in humans

Abstract

A useful method of studying the degree of association between two signals of varying amplitude in the time domain is to use cross-correlation analysis. We applied this to the movement-related cortical potentials digitally filtered so as to eliminate the low frequency component before applying it during maximal unilateral left (UL L), unilateral right (UL R) and bilateral (BL) contractions in 11 right-handed subjects. The recording electrode sites were over the right and left motor cortex areas (C3 and C4). The BL condition revealed higher cross-correlation levels of cortical activities between the two hemispheres than in UL L or UL R contraction [UL L, r = 0.68 (SEM 0.05); UL R, r = 0.73 (SEM 0.03); BL, r = 0.76 (SEM 0.02)]. The UL R revealed a positive phase difference [5 (SEM 2) ms] when the maximal cross-correlation coefficient was shown and UL L showed a negative phase difference [5 (SEM 3) ms]. However, BL revealed a smaller phase difference [2 (SEM 1) ms] than that for UL. It was concluded that during maximal BL contraction cortical cellular activities in both hemispheres was more synchronized in amplitude and time course compared with maximal UL contractions. Our data suggested that central common drive existed between the right and left motor areas during the maximal BL handgrip contractions and the amplitude of potentials of both hemispheres was modified by the interhemispheric inhibition mechanism as reported in other studies.