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. 1996 Oct;53(2):116-7.
doi: 10.1002/(SICI)1096-8652(199610)53:2<116::AID-AJH9>3.0.CO;2-2.

Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine

Y Asakura  1 , K Hamajima, J Fukushima, H Mohri, T Okubo, K Okuda
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Free article

Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine

Y Asakura et al. Am J Hematol. 1996 Oct.
Free article

Abstract

Recently, some individuals who have remained seronegative despite definite exposure to HIV-1 have been reported. Among these individuals, an unusually high frequency of HIV-1 Nef-specific cytotoxic T lymphocytes was observed. Direct injection of plasmid DNA encoding foreign antigen can elicit both cell-mediated immunity and antibody responses (DNA vaccine). We constructed an HIV-1 Nef-expressing plasmid, and we induced HIV-1 Nef-specific cytotoxic T lymphocytes. This is the first report of inducing HIV-1 Nef-specific cytotoxic T lymphocytes by DNA vaccine.

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