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. 1996 Nov;70(11):8234-40.
doi: 10.1128/JVI.70.11.8234-8240.1996.

Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy

P M Cannon  1 , N Kim, S M Kingsman, A J Kingsman
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Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy

P M Cannon et al. J Virol. 1996 Nov.

Abstract

We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.

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References

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