Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Nov 15;274(5290):1201-4.
doi: 10.1126/science.274.5290.1201.

Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae

W Zachariae  1 , T H Shin, M Galova, B Obermaier, K Nasmyth
Affiliations

Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae

W Zachariae et al. Science. .

Abstract

Entry into anaphase and proteolysis of B-type cyclins depend on a complex containing the tetratricopeptide repeat proteins Cdc16p, Cdc23p, and Cdc27p. This particle, called the anaphase-promoting complex (APC) or cyclosome, functions as a cell cycle-regulated ubiquitin-protein ligase. Two additional subunits of the budding yeast APC were identified: The largest subunit, encoded by the APC1 gene, is conserved between fungi and vertebrates and shows similarity to BIMEp from Aspergillus nidulans. A small heat-inducible subunit is encoded by the CDC26 gene. The yeast APC is a 36S particle that contains at least seven different proteins.

PubMed Disclaimer

Publication types

MeSH terms