Arterial homografts
- PMID: 8896468
- DOI: 10.1016/s1078-5884(96)80244-9
Arterial homografts
Abstract
Arterial allografts, formerly called homografts, came into limited use in the 1940s and 1950s as arterial substitutes. Fresh allografts underwent rapid rejection. Preserved allografts had a longer but still limited clinical life. Allografts demonstrated that arterial replacement was a valid concept and led to the development of synthetic substitutes. Recent renewed interest is based on the need for graft replacements in re-do procedures and in an infected field. Even the best methods of graft procurement and preservation do not preserve normal endothelial and smooth muscle cell functions nor eliminate antigenicity. The biologic and economic costs of immune suppression to obtain a successful allograft for an ischaemic limb are presently unjustifiable. Transplantation between species (xenotransplantation) may be attainable via selective inhibition of the complement system avoiding full immunosuppression now required for organ transplantation. At present allografts may be an acceptable choice for the patient with (1) a critical need for revascularisation and with a life expectancy not exceeding that of the graft, (2) in urgent vascular trauma, and (3) where immunosuppression is contraindicated as in an infected surgical field. Except in most unusual circumstances allografts should not be used for (1) relief of claudication, (2) in the above mid-calf location and (3) anatomic locations where synthetic grafts are superior.
Similar articles
-
[Arterial allografts in vascular surgery--best choice in cases of aortic graft infection?!].Zentralbl Chir. 2013 Oct;138(5):530-5. doi: 10.1055/s-0032-1328624. Epub 2013 Jul 3. Zentralbl Chir. 2013. PMID: 23824616 Review. German.
-
Cryopreserved arterial homografts vs silver-coated Dacron grafts for abdominal aortic infections with intraoperative evidence of microorganisms.J Vasc Surg. 2011 May;53(5):1274-1281.e4. doi: 10.1016/j.jvs.2010.11.052. Epub 2011 Feb 2. J Vasc Surg. 2011. PMID: 21292430
-
Cellular repopulation of human vein allograft bypass grafts.J Vasc Surg. 2000 May;31(5):994-1002. doi: 10.1067/mva.2000.105676. J Vasc Surg. 2000. PMID: 10805891 Clinical Trial.
-
[In situ replacement of infected vascular prosthesis with fresh arterial homograft: early and long-term results in 18 patients].Srp Arh Celok Lek. 2013 Nov-Dec;141(11-12):750-7. doi: 10.2298/sarh1312750p. Srp Arh Celok Lek. 2013. PMID: 24502092 Serbian.
-
The pathogenesis of hyperacute xenograft rejection.Am J Kidney Dis. 1992 Oct;20(4):414-21. doi: 10.1016/s0272-6386(12)70310-4. Am J Kidney Dis. 1992. PMID: 1415213 Review.
Cited by
-
Abdominal aorta transplantation after programmed cryopreservation.World J Gastroenterol. 2004 Feb 15;10(4):555-9. doi: 10.3748/wjg.v10.i4.555. World J Gastroenterol. 2004. PMID: 14966916 Free PMC article.
-
Immunological Aspects Involved in the Degeneration of Cryopreserved Arterial Allografts.Front Surg. 2020 Dec 22;7:616654. doi: 10.3389/fsurg.2020.616654. eCollection 2020. Front Surg. 2020. PMID: 33415125 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources