Influence of enalapril on experimental cyclosporin A nephrotoxicity
- PMID: 8897568
- DOI: 10.1007/s004670050173
Influence of enalapril on experimental cyclosporin A nephrotoxicity
Abstract
The purpose of this study was to investigate if enalapril could be administered with cyclosporin A (CyA) to reduce its nephrotoxicity. Sixty rats were divided into five groups: group I, Control group; group II, rat treated with oral enalapril; group III, rats treated with CyA: group IV, rats treated with CyA and enalapril; group V, rats treated with enalapril before the CyA therapy. At the end of the therapy mean serum creatinine concentrations were not statistically different between the groups (P > 0.05), in groups treated with CyA there were no statistically significant differences between mean CyA levels (P > 0.05), and mean blood urea nitrogen levels of the groups treated with CyA were significantly elevated (P < 0.05) compared with groups not treated with CyA. Morphologically acute CyA nephrotoxicity was evaluated by the following features: (1) tubular vacuolization, (2) tubular necrosis, (3) tubular microcalcification, and (4) peritubular capillary congestion. These lesions were scored semiquantitatively on a scale from 0 to 4+. The most common tubular pathology was tubular vacuolization, which was more severe in groups III and IV. Tubular necrosis was most severe in group III. In conclusion, enalapril seems to suppress the severest form of CyA nephrotoxicity, namely tubular necrosis, if administered prior to CyA treatment.
Similar articles
-
Effects of combination of cyclosporine with losartan or enalapril on kidney function in uremic rats.Pol J Pharmacol. 2002 Sep-Oct;54(5):469-73. Pol J Pharmacol. 2002. PMID: 12593533
-
Effects of STZ-induced diabetes and its treatment with vanadyl sulphate on cyclosporine A-induced nephrotoxicity in rats.Arch Toxicol. 2005 Sep;79(9):493-9. doi: 10.1007/s00204-005-0663-7. Epub 2005 Jun 7. Arch Toxicol. 2005. PMID: 15940472
-
Toxic effect of concomitant administration of cyclosporin A and acyclovir on renal function and morphology in rats.Arch Toxicol. 1997;71(9):556-62. doi: 10.1007/s002040050427. Arch Toxicol. 1997. PMID: 9285038
-
Enalaprilat directly ameliorates in vitro cyclosporin nephrotoxicity in human tubulo-interstitial cells.Nephron. 2000 Dec;86(4):473-81. doi: 10.1159/000045837. Nephron. 2000. PMID: 11124597
-
Enalapril in subantihypertensive dosage attenuates kidney proliferation and functional recovery in normotensive ablation nephropathy of the rat.Physiol Res. 1999;48(6):429-35. Physiol Res. 1999. PMID: 10783907
Cited by
-
Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria.Pediatr Nephrol. 2011 Mar;26(3):411-7. doi: 10.1007/s00467-010-1723-7. Epub 2010 Dec 24. Pediatr Nephrol. 2011. PMID: 21184240
-
Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats.Braz J Med Biol Res. 2017 Dec 11;51(2):e6373. doi: 10.1590/1414-431X20176373. Braz J Med Biol Res. 2017. PMID: 29267497 Free PMC article.
-
Cyclosporin A for the treatment of severe Henoch-Schönlein glomerulonephritis.Pediatr Nephrol. 2003 Nov;18(11):1138-42. doi: 10.1007/s00467-003-1245-7. Epub 2003 Aug 19. Pediatr Nephrol. 2003. PMID: 12928858 Clinical Trial.