Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins
- PMID: 8899962
- DOI: 10.1016/0966-842X(96)10061-5
Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins
Abstract
Some Clostridium species produce ABX-type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.
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