Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996 Oct;4(10):394-400.
doi: 10.1016/0966-842X(96)10059-7.

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

M K Slifka  1 , R Ahmed
Affiliations
Review

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

M K Slifka et al. Trends Microbiol. 1996 Oct.

Abstract

Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.

PubMed Disclaimer

Comment in

  • B cell longevity and immunological memory.
    Michie CA, Lampert IA. Michie CA, et al. Trends Microbiol. 1997 May;5(5):180-1. doi: 10.1016/S0966-842X(97)85011-1. Trends Microbiol. 1997. PMID: 9160504 No abstract available.

References

    1. Ahmed R., Gray D. Science. 1996;272:54–60. - PubMed
    1. Kempe C.H. Bull. WHO. 1961;25:41–48. - PMC - PubMed
    1. Krugman S. New Engl. J. Med. 1963;269:195–201. - PubMed
    1. McDonald J.C. Br. Med. J. 1963;2:416–418. - PMC - PubMed
    1. Vieira P., Rajewsky K. Eur. J. Immunol. 1988;18:313–316. - PubMed

Substances