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Comparative Study
. 1977 Jul;84(7):53-6.

[Nitrazepam metabolism in the intestines of white rats]

[Article in Russian]
N Ia Golovenko, A V Bogatskiĭ, E I Orliuk, A A Kurushin, T L Karaseva
  • PMID: 890136
Comparative Study

[Nitrazepam metabolism in the intestines of white rats]

[Article in Russian]
N Ia Golovenko et al. Biull Eksp Biol Med. 1977 Jul.

Abstract

Nitrasepam is transformed to amino and acetamide derivatives in the rat intestine. Reduction of nitrasepam and its following acetylation in the duodenum and small intestine are catalyzed by the mucosal enzymes. In the cecum and the large intestine these processes are mediated through the action of the microbes and tissue enzymes, whereas in the rectum--through the microbes only.

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