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Review
. 1995;22(2-3):147-50.
doi: 10.1007/BF00988720.

Structure, mechanism and evolution of chloroplast transfer RNA processing systems

P Gegenheimer  1
Affiliations
Review

Structure, mechanism and evolution of chloroplast transfer RNA processing systems

P Gegenheimer. Mol Biol Rep. 1995.

Abstract

Chloroplasts of land plants have an active transfer RNA processing system, consisting of an RNase P-like 5' endonuclease, a 3' endonuclease, and a tRNA:CCA nucleotidyltransferase. The specificity of these enzymes resembles more that of their eukaryotic counterparts than that of their cyanobacterial predecessors. Most strikingly, chloroplast RNase P activity almost certainly resides in a protein, rather than in an RNA.protein complex as in Bacteria, Archaea, and Eukarya. The chloroplast enzyme may have evolved from a preexisting chloroplast NADP-binding protein. Chloroplast RNase P cleaves pre-tRNA by a reaction mechanism in which at least one of the Mg2+ ions utilized by the bacterial ribozyme RNase P is replaced by an amino acid side chain.

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