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Review
. 1996 Oct 29;93(22):12142-9.
doi: 10.1073/pnas.93.22.12142.

The N-end rule: functions, mysteries, uses

A Varshavsky  1
Affiliations
Review

The N-end rule: functions, mysteries, uses

A Varshavsky. Proc Natl Acad Sci U S A. .

Abstract

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.

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References

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    1. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2234-8 - PubMed
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    1. Science. 1996 Sep 20;273(5282):1725-8 - PubMed
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