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. 1996 Oct 29;93(22):12445-50.
doi: 10.1073/pnas.93.22.12445.

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium

V Groh  1 , S Bahram, S Bauer, A Herman, M Beauchamp, T Spies
Affiliations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium

V Groh et al. Proc Natl Acad Sci U S A. .

Abstract

Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is not associated with beta 2-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium. Thus, this MHC class I molecule may function as an indicator of cell stress and may be recognized by a subset of gut mucosal T cells in an unusual interaction.

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