Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Oct 29;93(22):12456-60.
doi: 10.1073/pnas.93.22.12456.

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro

N Platt  1 , H Suzuki, Y Kurihara, T Kodama, S Gordon
Affiliations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro

N Platt et al. Proc Natl Acad Sci U S A. .

Abstract

Numerous immature thymocytes undergo apoptosis and are rapidly engulfed by phagocytic thymic macrophages. The macrophage surface receptors involved in apoptotic thymocyte recognition are unknown. We have examined the role of the class A macrophage scavenger receptor (SR-A) in the engulfment of apoptotic thymocytes. Uptake of steroid-treated apoptotic thymocytes by thymic and inflammatory-elicited SR-A positive macrophages is partially inhibited by an anti-SR-A mAb and more completely by a range of scavenger receptor ligands. Thymic macrophages from mice with targeted disruption of the SR-A gene show a 50% reduction in phagocytosis of apoptotic thymocytes in vitro. These data suggest that SR-A may play a role in the clearance of dying cells in the thymus.

PubMed Disclaimer

References

    1. J Immunol Methods. 1987 Oct 23;103(1):59-67 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5646-50 - PubMed
    1. Annu Rev Immunol. 1988;6:309-26 - PubMed
    1. Nature. 1990 Jan 11;343(6254):170-3 - PubMed
    1. Nature. 1990 Feb 8;343(6258):531-5 - PubMed

Publication types