Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Oct;13(5):741-7.
doi: 10.1007/BF00702338.

Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins

P L Stranahan  1 , J Laroe, R McCombs, A Goldsmith, I Rahim, M Overland, D E Pettijohn
Affiliations

Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins

P L Stranahan et al. Glycoconj J. 1996 Oct.

Abstract

Intratumoral phenotypic diversity is well documented with regard to tumor associated carbohydrate antigens (TACA). The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at different surface densities (number of cells per cm2 of growth flask). Results show that the apparent expression of extended Lea-Lex, Lea and Lex, sialyl Lea, Tn and sialyl Tn varies with density of growth by an invasive human squamous cell lung carcinoma cell line (NU6-1), a benign variant (NE-18) and the human lung epithelial cell line BEAS-2B. The results indicate that one of the factors influencing the apparent expression of mucin-associated oligosaccharides is cell-cell interactions.

PubMed Disclaimer

References

    1. Glycobiology. 1993 Apr;3(2):97-130 - PubMed
    1. Biochemistry. 1994 Sep 6;33(35):10672-80 - PubMed
    1. Glycoconj J. 1992 Oct;9(5):217-21 - PubMed
    1. Cancer Res. 1987 Feb 15;47(4):1161-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Feb;85(3):802-6 - PubMed

Publication types

MeSH terms