Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Nov 22;274(5291):1371-4.
doi: 10.1126/science.274.5291.1371.

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

J R Smith  1 , D Freije, J D Carpten, H Grönberg, J Xu, S D Isaacs, M J Brownstein, G S Bova, H Guo, P Bujnovszky, D R Nusskern, J E Damber, A Bergh, M Emanuelsson, O P Kallioniemi, J Walker-Daniels, J E Bailey-Wilson, T H Beaty, D A Meyers, P C Walsh, F S Collins, J M Trent, W B Isaacs
Affiliations

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

J R Smith et al. Science. .

Abstract

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

PubMed Disclaimer

Comment in

  • Homing in on prostate cancer gene.
    Pennisi E. Pennisi E. Science. 1996 Nov 22;274(5291):1301. doi: 10.1126/science.274.5291.1301a. Science. 1996. PMID: 8966598 No abstract available.

Publication types

Substances