Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Nov 22;274(5291):1389-91.
doi: 10.1126/science.274.5291.1389.

Control of C. elegans larval development by neuronal expression of a TGF-beta homolog

P Ren  1 , C S Lim, R Johnsen, P S Albert, D Pilgrim, D L Riddle
Affiliations

Control of C. elegans larval development by neuronal expression of a TGF-beta homolog

P Ren et al. Science. .

Abstract

The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources