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. 1977 Jul;29(1):176-80.

Effect of A. laidlawii on murine and human lymphocyte cultures

H Kirchner, H Brunner, H Rühl

Effect of A. laidlawii on murine and human lymphocyte cultures

H Kirchner et al. Clin Exp Immunol. 1977 Jul.

Abstract

Heat-inactivated A. laidlawii (AL) was found to be a potent mitogen for mouse spleen cells. Spleen cells from homozygous nude mice and spleen cells treated with anti-theta serum and complement responded as well as their respective controls, indicating that AL represented a B-cell mitogen for mouse spleen cells. Spleen cells from LPS-unresponsive C3H/Hej mice responded well to AL. The peripheral blood leucocytes from unselected human donors were also stimulated by AL, which appeared to represent a T-cell mitogen for human leucocytes. However, the possibility that it acted as a specific antigen could not be excluded. Attention was drawn to the possibility that the presence of mycoplasma might considerably affect the results of tests where tissue-culture cells or derivatives thereof are added to leucocyte cultures.

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References

    1. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41-9 - PubMed
    1. Proc Soc Exp Biol Med. 1966 Dec;123(3):790-5 - PubMed
    1. Infect Immun. 1976 Jun;13(6):1663-70 - PubMed
    1. Nat New Biol. 1973 Dec 5;246(153):143-6 - PubMed
    1. J Exp Med. 1976 Sep 1;144(3):840-6 - PubMed

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