Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Nov;40(11):2523-8.
doi: 10.1128/AAC.40.11.2523.

Distribution of genes encoding resistance to streptogramin A and related compounds among staphylococci resistant to these antibiotics

J Allignet  1 , S Aubert, A Morvan, N el Solh
Affiliations

Distribution of genes encoding resistance to streptogramin A and related compounds among staphylococci resistant to these antibiotics

J Allignet et al. Antimicrob Agents Chemother. 1996 Nov.

Abstract

The levels of resistance to pristinamycin (Pt) and to its major constituents, pristinamycin IIA and IB (PIIA and PIB, respectively; classified as streptogramins A and B, respectively) were determined for 126 staphylococcal isolates. The results suggest tentative susceptibility breakpoints of < or = 2, < or = 8, and < or = 0.5 microgram/ml for PIIA, PIB, and Pt, respectively. Fifty-six isolates that were inhibited by > or = 4 micrograms of PIIA per ml were investigated for the presence of staphylococcal genes encoding resistance to PIIA (vga, vat, and vatB) and PIB (vgb). None of these genes was found in the 4 isolates inhibited by 4 micrograms of PIIA per ml or in 4 of the other 52 isolates tested. The remaining 48 isolates harbored plasmids carrying vatB and vga or combinations of genes (vga-vat-vgb or vga-vat). The absence of any known PIIA resistance gene from the four Staphylococcus aureus isolates inhibited by > or = 8 micrograms of PIIA per ml suggests that there is at least one PIIA resistance mechanism in staphylococci that has not yet been characterized.

PubMed Disclaimer

References

    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Antimicrob Agents Chemother. 1995 Jan;39(1):238-40 - PubMed
    1. Microbiol Rev. 1979 Jun;43(2):145-92 - PubMed
    1. Antimicrob Agents Chemother. 1986 Jul;30(1):161-9 - PubMed
    1. Plasmid. 1980 Jul;4(1):117-20 - PubMed

MeSH terms