Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1996 Nov;40(11):2661-3.
doi: 10.1128/AAC.40.11.2661.

Comparative activities of LY 333328, a new glycopeptide, against penicillin-susceptible and -resistant pneumococci

E Fasola  1 , S K Spangler, L M Ednie, M R Jacobs, S Bajaksouzian, P C Appelbaum
Affiliations
Comparative Study

Comparative activities of LY 333328, a new glycopeptide, against penicillin-susceptible and -resistant pneumococci

E Fasola et al. Antimicrob Agents Chemother. 1996 Nov.

Abstract

Microdilution MIC testing was used to test the susceptibility of 202 pneumococci to LY 333328 and six other agents. LY 333328 was the most active glycopeptide (MIC at which 90% of the pneumococci were inhibited [MIC90], 0.008 microgram/ml), followed by teicoplanin (MIC90, 0.06 microgram/ml) and vancomycin (MIC90, 0.5 microgram/ml). Rifampin resistance was seen in some penicillin-resistant strains. The MICs of imipenem and ceftriaxone rose with those of penicillin. Time-kill testing confirmed the excellent antipneumococcal activity of LY 333328.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1991 Dec;35(12):2467-72 - PubMed
    1. Clin Infect Dis. 1992 Jul;15(1):119-27 - PubMed
    1. Clin Infect Dis. 1992 Jul;15(1):77-83 - PubMed
    1. Antimicrob Agents Chemother. 1992 Apr;36(4):856-9 - PubMed
    1. Eur J Clin Microbiol Infect Dis. 1994 Jan;13(1):33-4 - PubMed

Publication types