Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Nov;144(3):967-78.
doi: 10.1093/genetics/144.3.967.

Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth

H Liu  1 , C A Styles, G R Fink
Affiliations

Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth

H Liu et al. Genetics. 1996 Nov.

Abstract

Diploid strains of baker's yeast Saccharomyces cerevisiae can grow in a cellular yeast form or in filaments called pseudohyphae. This dimorphic transition from yeast to pseudohyphae is induced by starvation for nitrogen. Not all laboratory strains are capable of this dimorphic switch; many grow only in the yeast form and fail to form pseudohyphae when starved for nitrogen. Analysis of the standard laboratory strain S288C shows that this defect in dimorphism results from a nonsense mutation in the FLO8 gene. This defect in FLO8 blocks pseudohyphal growth in diploids, haploid invasive growth, and flocculation. Since feral strains of S. cerevisiae are dimorphic and have a functional FLO8 gene, we suggest that the flo8 mutation was selected during laboratory cultivation.

PubMed Disclaimer

References

    1. Mol Biol Cell. 1994 Sep;5(9):1003-22 - PubMed
    1. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5352-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Genetics. 1981 May;98(1):41-54 - PubMed
    1. Gene. 1984 Jun;28(3):351-9 - PubMed

Publication types

Associated data