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. 1977 Jul 19;11(6):459-61.
doi: 10.1007/BF00562939.

Binding of 16alpha-gitoxin and its 16-acetate to human serum albumin

M Richter, K O Haustein

Binding of 16alpha-gitoxin and its 16-acetate to human serum albumin

M Richter et al. Eur J Clin Pharmacol. .

Abstract

The binding of semi-synthetic (16alpha-gitoxin and its 16-acetate) and naturally occurring cardioactive glycosides (digitoxin, ouabain) to human serum albumin was studied using equilibrium dialysis, ultracentrifugation and gel filtration. 16alpha-gitoxin was 75% bound and its 16-acetate 95%. The percentage binding of digitoxin and ouabain was in good agreement with values reported in literature.

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References

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