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. 1977 Aug 1;44(3):271-3.
doi: 10.1016/0014-2999(77)90073-5.

Stimulation of prostaglandin output from rat stomach by hypertonic solutions

G Assouline, V Leibson, A Danon

Stimulation of prostaglandin output from rat stomach by hypertonic solutions

G Assouline et al. Eur J Pharmacol. .

Abstract

A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline--hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.

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