Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug 8;29(1):137-47.
doi: 10.1007/BF00236881.

Synaptogenesis and myelinogenesis in dissociated cerebral cells from rat embryo on polylysine coated surfaces

Z Yavin, E Yavin

Synaptogenesis and myelinogenesis in dissociated cerebral cells from rat embryo on polylysine coated surfaces

Z Yavin et al. Exp Brain Res. .

Abstract

The appearance of myelinated axons and establishment of synaptic contracts in dissociated cells from rat embryo cerebral hemispheres grown on polylysine precoated surfaces were studied by light and electron microscopy. Typical myelin lamellae ensheathing axons were observed as early as the eighth day. Immature synaptic profiles exhibiting slight membrane thickening and few synaptic vesicles were observed after seven days. At 3 weeks, mature synapses containing many synaptic vesicles and the typical irregular membrane thickening could be seen. It is suggested that the presence of polylysine may provide a support which enhances the attachment and subsequent establishment of contacts between neuronal and glial cells, resulting in the early onset of myelin formation.

PubMed Disclaimer

References

    1. Exp Brain Res. 1975 Jul 11;23(1):29-47 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3219-22 - PubMed
    1. J Ultrastruct Res. 1969 Jan;26(1):31-43 - PubMed
    1. J Cell Biol. 1973 Apr;57(1):232-7 - PubMed
    1. J Neurocytol. 1975 Dec;4(6):713-32 - PubMed