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Review
. 1996 Nov 12;93(23):12756-8.
doi: 10.1073/pnas.93.23.12756.

Virus-lymphoid cell interactions

M B Oldstone  1
Affiliations
Review

Virus-lymphoid cell interactions

M B Oldstone. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
A mechanism for how MV-induced suppression of lymphocyte proliferation may occur via cell–cell interactions mediated by MV glycoproteins. The interaction of a lymphocyte (LY) with MV hemagglutinin (H) and/or fusion (F) proteins expressed on the surface of an infected cell delivers a transmembrane signal (zig-zag arrows) to the responding cell, which arrests its proliferation (−). Adhesion proteins (striped bars) may facilitate suppression by enhancing cell–cell interactions. What the ligand(s) on the uninfected cell are, or the signal, is unknown. The cartoon shows the proposed interaction between an infected cell (displayed as an antigen-presenting cell: APC) and an uninfected cell. Evidence for components of this model is provided by Schlender et al. (2) and was proposed earlier by Borrow and Oldstone (28). [Reprinted with permission from ref. (Copyright 1995, Springer, Berlin).]
See this image and copyright information in PMC

Comment on

References

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    1. Schlender J, Schnorr J-J, Spielhofer P, Cathomen T, Caltaneo R, Billeter M A, ter Meulen V, Schneider-Schavlies S. Proc Natl Acad Sci USA. 1996;93:13194–13199. - PMC - PubMed
    1. Blackbourn D J, Mackewicz C E, Barker E, Hunt T K, Hemdier B, Haase A T, Levy T. Proc Natl Acad Sci USA. 1996;93:13125–13130. - PMC - PubMed
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