doi: 10.1093/jnci/63.3.745.
Inhibition of spontaneous transformation of rat embryo cells releasing endogenous type C virus by virus-specific antiserum
- PMID: 89211
- DOI: 10.1093/jnci/63.3.745
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Inhibition of spontaneous transformation of rat embryo cells releasing endogenous type C virus by virus-specific antiserum
J Natl Cancer Inst.
1979 Sep.
Abstract
Noninbred Sprague-Dawley rat embryo cell clones predictably undergo transformation after 20-30 in vitro passages following spontaneous release of endogenous rat leukemia virus (RaLV). In the presence of RaLV-specific antiserum, virus production and infectivity were reduced and transformation was delayed from 6 to 25 weeks. Transformation was not associated with an increased expression of Kirsten murine sarcoma virus-related src gene RNA.
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