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. 1996 Oct 1;37(1):19-23.
doi: 10.1006/geno.1996.0515.

Molecular characterization of a nonneuronal human UNC18 homolog

S F Ziegler  1 , M T Mortrud, A R Swartz, E Baker, G R Sutherland, M Burmeister, J T Mulligan
Affiliations

Molecular characterization of a nonneuronal human UNC18 homolog

S F Ziegler et al. Genomics. .

Abstract

A cDNA clone encoding a human homolog of the Caenorhabditis elegans unc-18 gene was identified following random sequencing of clones from IL-2-activated human NK cells. This cDNA clone is related to the nonneuronal Munc-18b and so has been called Hunc-18b. The Hunc-18b transcripts were found in most human tissues, with the exception of brain and skeletal muscle, and in cells from all lymphoid lineages. The Hunc-18b gene was localized to human chromosome 19p13.2-p13.3, and the mouse homolog, Munc-18b, was mapped to the proximal region of mouse Chromosome 8.

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