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. 1996 Sep;52(3):874-85.

A regression survival model for testing the proportional hazards hypothesis

C Quantin  1 , T Moreau, B Asselain, J Maccario, J Lellouch
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  • PMID: 8924576

A regression survival model for testing the proportional hazards hypothesis

C Quantin et al. Biometrics. 1996 Sep.

Abstract

A semi-parametric generalization of the proportional hazards regression model is defined, whereby the hazard functions can cross for different values of the covariates. In the two-sample comparison, it includes in particular the case of two Weibull distributions differing in scale and shape parameters. A global test of the proportional hazards assumption is proposed against such defined alternatives. Its power in the two-sample case is compared to that of previously described tests by using simulation experiments. Survival data of patients with breast carcinoma, including several prognostic factors, are presented as an illustration.

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