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Comparative Study
. 1996 Feb;20(1):1-9.
doi: 10.1007/BF01487740.

Comparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cells

K E Foreman  1 , M M Glovsky, R L Warner, S J Horvath, P A Ward
Affiliations
Free article
Comparative Study

Comparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cells

K E Foreman et al. Inflammation. 1996 Feb.
Free article

Abstract

Complement activation is known to enhance neutrophil binding to human umbilical vein endothelial cells (HUVECs). Recently, we have shown that recombinant human C5a upregulates P-selectin in HUVECs. Unstimulated human neutrophil binding is also increased on C5a stimulated HUVECs. We demonstrate in this report that C5a upregulates CD11b/CD18 in human neutrophils. Also shown is that synthetic C3a57-77 and an analog 15 amino acid C3a peptide (C3a15) neither upregulate CD11b/CD18 nor do the C3a peptides increase P-selectin, ICAM-1 or E-selectin in HUVECs. Thus C5a and not C3a is responsible for early (approximately 30 minutes) neutrophil adhesion to endothelial cells after complement activation.

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