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. 1996 Jul;53(7):678-80.
doi: 10.1001/archneur.1996.00550070116019.

Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia

V J Kattapong  1 , W M Brooks, M H Wesley, P W Kodituwakku, G A Rosenberg
Affiliations

Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia

V J Kattapong et al. Arch Neurol. 1996 Jul.

Abstract

Objective: To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.

Design and subjects: Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.

Results: The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02).

Conclusion: Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

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