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Comparative Study
. 1996 Oct;27(5):351-3.
doi: 10.1111/j.1365-2052.1996.tb00977.x.

The porcine TTR locus maps to chromosome 6q

A L Archibald  1 , S Couperwhite, Z H Jiang
Affiliations
Comparative Study

The porcine TTR locus maps to chromosome 6q

A L Archibald et al. Anim Genet. 1996 Oct.

Abstract

The sequence of a cDNA clone encoding porcine transthyretin (prealbumin) was used to develop polymorphic markers for the TTR locus. The single-strand conformation polymorphism (SSCP) detected is caused by a silent A/T mutation in the penultimate coding codon and can also be revealed as a SacI restriction fragment length polymorphism (RFLP). The TTR locus was mapped to chromosome 6q by segregation and linkage analysis with these polymorphisms. This assignment confirms the predictions of homology between human chromosome 18 and pig chromosome 6q2.5-q2.6.

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