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. 1977 Jul;30(7):552-63.
doi: 10.7164/antibiotics.30.552.

Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification

R S Egan, R S Stanaszek, M Cirovic, S L Mueller, J Tadanier, J R Martin, P Collum, A W Goldstein, R L De Vault, A C Sinclair, E E Fager, L A Mitscher
Free article

Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification

R S Egan et al. J Antibiot (Tokyo). 1977 Jul.
Free article

Abstract

The structures of fortimicins A and B have been determined by PMR, CMR, mass spectra and CD combined with chemical degradations. Both antibiotics are pseudodisaccharides and incorporate a novel aminocyclitol, fortamine. In contrast to the diaminocyclitol moieties of known aminoglycosides, fortamine is a 1,4-diamine, contains both N- and O-methyl groups and possesses chiro stereochemistry. Both antibiotics are glycosides of 6-epi-purpurosamine B, but fortimicin A differs from fortimicin B by being a glycyl amide.

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