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. 1979 Aug 4;2(8136):224-6.
doi: 10.1016/s0140-6736(79)90238-1.

Antithyroid-antibody activity in the snyovial fluid of patients with various arthritides

D R Blake, A M McGregor, E Stansfield, B R Smith

Antithyroid-antibody activity in the snyovial fluid of patients with various arthritides

D R Blake et al. Lancet. .

Abstract

Microsomal and thyroglobulin autoantibody activity has been detected in synovial fluid from 34 of 50 patients with various arthritides (rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis, and gout). Serum from only 4 of these patients showed thyroid-autoantibody activity, and the serum titres were considerably lower than the synovial-fluid titres. This suggests that thyroid autoantibody is produced locally in the joints of these patients.

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