Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain
- PMID: 893404
Item in Clipboard
Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain
J Biol Chem.
.
Free article
Abstract
A novel trisialoganglioside has been isolated from normal adult human brain in a yield of 0.6% of the total gangkioside. By graded neuraminidase treatment, mild acid hydrolysis and periodate oxidation analysis, the ganglioside was identified as GT1a having the following structure: NeuAc(alpha, 2-8)NeuAc(alpha, 2-3)Gal(beta, 1-3)GalNAc(beta, 1-4) [NeuAc(alpha, 2-3)]Gal(beta, 1-4)Glc(1-1)ceramide.
Similar articles
-
Isolation and characterization of a novel ganglioside, monosialosyl pentahexaosyl ceramide from human brain.J Biochem. 1978 Dec;84(6):1601-8. doi: 10.1093/oxfordjournals.jbchem.a132286. J Biochem. 1978. PMID: 739007
-
Isolation and characterization of GD3 ganglioside having a novel disialosyl residue from rabbit thymus.J Biol Chem. 1978 Nov 25;253(22):8328-31. J Biol Chem. 1978. PMID: 711756
-
Isolation and characterization of a novel monosialosylpentahexosyl ceramide from Tay-Sachs brain.J Biol Chem. 1981 Jan 10;256(1):165-9. J Biol Chem. 1981. PMID: 7451432
-
The chemical constitution of gangliosides of the vertebrate nervous system.Behav Brain Res. 1995 Jan 23;66(1-2):85-97. doi: 10.1016/0166-4328(94)00129-4. Behav Brain Res. 1995. PMID: 7755905 Review.
-
Brain gangliosides: functional ligands for myelin stability and the control of nerve regeneration.Biochimie. 2001 Jul;83(7):677-82. doi: 10.1016/s0300-9084(01)01308-6. Biochimie. 2001. PMID: 11522397 Review.
Cited by
-
Gangliosides and neutral glycolipids in ependymal, neuronal and primitive neuroectodermal tumors.J Mol Neurosci. 1999 Apr;12(2):111-21. doi: 10.1007/BF02736925. J Mol Neurosci. 1999. PMID: 10527455
-
Analysis of glycosphingolipid-derived oligosaccharides by high pH anion exchange chromatography.Glycoconj J. 1994 Jun;11(3):249-56. doi: 10.1007/BF00731225. Glycoconj J. 1994. PMID: 7841800
-
Two species of antiganglioside antibodies in a patient with a pharyngeal-cervical-brachial variant of Guillain-Barré syndrome.J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1121-3. doi: 10.1136/jnnp.57.9.1121. J Neurol Neurosurg Psychiatry. 1994. PMID: 8089683 Free PMC article.
-
Anti-GT1a IgG in Guillain-Barré syndrome.J Neurol Neurosurg Psychiatry. 2002 Jun;72(6):767-71. doi: 10.1136/jnnp.72.6.767. J Neurol Neurosurg Psychiatry. 2002. PMID: 12023422 Free PMC article.
-
Anti-Chol-1 antigen, GQ1bα, antibodies are associated with Alzheimer's disease.PLoS One. 2013 May 23;8(5):e63326. doi: 10.1371/journal.pone.0063326. Print 2013. PLoS One. 2013. PMID: 23717411 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
