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. 1977 Sep 25;252(18):6247-50.

Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain

S Ando, R K Yu
  • PMID: 893404
Free article

Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain

S Ando et al. J Biol Chem. .
Free article

Abstract

A novel trisialoganglioside has been isolated from normal adult human brain in a yield of 0.6% of the total gangkioside. By graded neuraminidase treatment, mild acid hydrolysis and periodate oxidation analysis, the ganglioside was identified as GT1a having the following structure: NeuAc(alpha, 2-8)NeuAc(alpha, 2-3)Gal(beta, 1-3)GalNAc(beta, 1-4) [NeuAc(alpha, 2-3)]Gal(beta, 1-4)Glc(1-1)ceramide.

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