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. 1996 Feb;48(2):147-9.
doi: 10.1111/j.2042-7158.1996.tb07113.x.

Magnetizable solid-phase supports for purification of nucleic acids

I J Bruce  1 , M J Davies, K Howard, D E Smethurst, M Todd
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Magnetizable solid-phase supports for purification of nucleic acids

I J Bruce et al. J Pharm Pharmacol. 1996 Feb.

Abstract

A simple, small scale non-hazardous procedure for the production of magnetizable solid-phase support (MSPS) beads has been developed based on the extrusion of agarose/iron oxide mixtures. The MSPS beads were derivatized using various amine ligands. Derivatized MSPS beads were used to adsorb nucleic acids from aqueous solution and to separate RNA/DNA mixtures.

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