Negative inotropic effect of chagasic IgG mediated by nitric oxide
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- PMID: 8935488
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Negative inotropic effect of chagasic IgG mediated by nitric oxide
Acta Physiol Pharmacol Ther Latinoam.
1996.
Abstract
In this paper we analyse the interaction of IgG from T. cruzi infected patients with cardiac muscarinic acetylcholine receptors (mAChRs). Human chagasic IgG, activating M2 mAChR simulated the agonist actions excerting negative inotropic effect and stimulation of nitric oxide synthase (NOS). Inhibitors of phospholipase C, protein kinase C, calcium/calmodulin, NOS and guanylate cyclase activities prevented the chagasic effects upon contractility and NOS activity.
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